Figure 4. Re-accumulation of fluorescence imaging to the tumor site after PDT in mice administered ICG-lactosomes.

Accumulation of fluorescence imaging in mouse subcutaneous tumors after ICG or ICG-lactosomes administration was observed daily using IVIS. On the second day of administration, PDT irradiation (1150 mW/cm², 90 s (100 J/cm²)) was performed in the ICG (ICG (n = 5), open circles) and ICG-lactosomes-once-irradiated (ICG-Lact1 (n = 5), closed squares) groups. The second irradiation was performed on day 5 after the first PDT in the ICG-lactosomes-twice-irradiated group (ICG-Lact2 (n = 5), closed triangles). The results are presented as the mean ± SEM.