Figure 2.

Hippocampal mRNA levels of glucocorticoid target genes assessed in wild‐type (WT) and forebrain mineralocorticoid receptor (MR) knockout (fbMRKO) mice. Gene expression of (A) MR‐specific, (B) overlapping and (C) glucocorticoid receptor (GR)‐specific targets and (D) classical glucocorticoid targets in fbMRKO versus WT mice, as assessed by independent t‐tests with P < 0.01 as the statistically significant cut‐off. Other genes measured but not differentially expressed between WT and fbMRKO mice were: Adam23, Arl8b, Dgkb, Els1, Myo16 and Nob1 as MR‐specific targets; Grb2, Luzp1 and Map1lc3b as overlapping targets; Arntl, B3galt1, Map2k5, Pglyrp1 and Slc3a2 as GR‐specific targets. a.u., arbitrary unit. #P < 0.05 (considered a trend), **P < 0.01, ***P < 0.001, ****P < 0.0001