Table 3.

Animal studies of faecal microbiota transplantation for NAFLD

Publication	Study population	Study design/treatments	Primary outcomes
Nicolas et al 2017156	Donors: WT mice fed a high‐fat diet WT mice fed a normal calorie diet Genetically obese (ob/ob) mice Recipients: WT mice	Recipients were gavaged with gut microbiota obtained from cecum of (a) WT mice fed a normal diet; (b) WT mice fed a high‐fat diet; (c) genetically obese mice	Gut microbiota from both WT mice fed a high‐fat diet and genetically obese mice reduced hepatic gluconeogenesis and adiposity elicited by a high‐fat diet
Li et al 2015157	Donors: WT mice Recipients: WT mice that received ceftriaxone b.i.d. for 7 d to induce gut microbiota dysbiosis	Recipients gavaged for 3 d with faecal microbiota from WT mice or cultured bacteria initially isolated from donor mice faeces	Gavage with faecal microbiota from WT mice or cultured bacteria improved inflammatory cell infiltration, tissue architecture distortion and vascular congestion elicited by ceftriaxone Ceftriaxone‐induced intestinal permeability was significantly improved with administration of faecal microbiota or cultured bacteria after 1 and 2 wk vs untreated animals (P < 0.05)

Abbreviations: b.i.d., twice daily; WT, wild type.