Sentence 1: general description of arthrogryposis multiplex congenita (AMC) |
AMC is a term used to describe a group of congenital conditions characterized by joint contractures in two or more body areas |
Epidemiology, genetics, and orthopedics |
Sentence 2: causes |
While the precise cause may be unknown for some individuals, causes are variable and may include genetic, parental, and environmental factors, as well as abnormalities during fetal development |
Genetics and neurology |
Sentence 3: impact on joints and muscles |
Individuals with AMC have limited joint movement, with or without muscle weakness, in the involved body areas |
Plastic surgery and orthopedics |
Sentence 4: evolution of the clinical presentation |
Contractures vary in distribution and severity, do not progress to previously unaffected joints, but may change over time due to growth and treatment |
Physiotherapy, plastic surgery, and dentistry |
Sentence 5: impact on the spine |
Spinal deformities may be present at birth or develop throughout childhood and adolescence |
Orthopedics |
Sentence 6: impact on other body systems |
Depending on the underlying diagnosis, other body systems such as the central nervous system (CNS), respiratory, gastrointestinal, and genitourinary systems may be affected |
Neurology, genetics, epidemiology, and dentistry |
Sentence 7: impact on cognition and sensation |
Cognition may be affected if the CNS is involved; sensation is usually intact |
Neurology and orthopedics |
Sentence 8: impact on function |
The impact on mobility, activities of daily living and participation is variable |
Lived experience, genetics, occupational therapy, and dentistry |