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. 2019 Jul 8;145(9):2535–2546. doi: 10.1002/ijc.32531

Figure 1.

Figure 1

The combination of anti‐PD‐1 and SGT‐53 inhibits tumor growth. C57BL/6 mice with subcutaneous GL261 tumors were randomized to therapy with anti‐PD‐1 (200 μg antibody), SGT‐53 (30 μg DNA), or the combination of both agents twice weekly for 2.5 weeks. (a) Changes in tumor sizes were plotted. (b) Quantification of tumor weight at harvest on day 17. *p < 0.001, **p < 0.05, t‐test with ANOVA. n = 6. Red lines indicate average tumor weight. (c) Changes in gene expression of tumors using NanoString analysis. (d) Representative immunohistochemical staining of Casp3 and GzmB. Scale bars, 100 μm. Red dashed boxes indicate the magnified areas. Quantifications of positive stain of (e) Casp3 and (f) GzmB. *p < 0.001, t‐test with ANOVA (n = 8–12/group).