Table 2.
In vitro activity of pyrazolone dimers against intracellular amastigotes of T. cruzi (Tulahuen strain) and on MRC‐5 cells by dihydropyrazolone dimers with modification of the aromatic ring.
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---|---|---|---|
Compd | R2 | pIC50 [a] | |
T. cruzi | MRC‐5 | ||
11 a |
![]() |
<4.2 | <4.2 |
11 b |
![]() |
<4.2 | <4.2 |
11 c |
![]() |
<4.2 | <4.2 |
11 d |
![]() |
<4.2 | <4.2 |
11 e |
![]() |
<4.2 | <4.2 |
11 f |
![]() |
5.1 | <4.2 |
11 g | H | <4.2 | <4.2 |
[a] All reported values are within a standard deviation of ±0.2.