Table 3.

In vitro activity of pyrazolone dimers against intracellular amastigotes of T. cruzi (Tulahuen strain) and on MRC‐5 cell growth by dihydropyrazolone dimers with modification of the linker.

Compd	X	pIC50 [a]
		T. cruzi	MRC‐5
7 q		6.4	<4.2
12 a		<4.2	<4.2
12 b		4.3	<4.2
12 c		<4.2	<4.2
12 d		5.7	4.3
12 e		5.1	5.2
14		5.7	5.2
15		<4.2	<4.2

[a] All reported values are within a standard deviation of ±0.2.