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. 2019 Jun 22;86(2):215–224. doi: 10.1002/ana.25513

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© 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Addition of crenezumab does not alter the detection of oligomers of amyloid β (oAβ). Crenezumab or a control IgG4 antibody was spiked into (A) the amyloid‐beta–derived diffusible ligand (ADDL) standard or (B) 7 different control cerebrospinal fluid (CSF) samples at final concentrations of 5μg/ml, and the oAβ levels were measured. Samples treated with crenezumab are in blue and those treated with control antibody are in red. Each symbol is the mean of technical quadruplicates. DE = detected event.