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. 2019 Aug 12;71(9):1553–1570. doi: 10.1002/art.40906

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© 2019 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Main characteristics of the 6 clusters (clusters 1–6) of patients with systemic sclerosis (SSc). B, Left, Proportions of each cluster with the main clinical characteristics of diffuse cutaneous SSc (dcSSc), restrictive defect, and suspected pulmonary hypertension (PH) on echocardiography (echo). Right, Peak modified Rodnan skin thickness score (MRSS), mortality (per 1,000 patient‐years [py]), and percentages of patients with anticentromere antibodies (ACAs) and anti–topoisomerase I (anti–topo I) antibodies in each cluster. C, Kaplan‐Meier survival curves for the 6 clusters. D, Forest plot showing mortality hazard ratios and 95% confidence intervals for the 6 clusters. Broken line shows the hazard ratio for the reference group. Colors represent the different clusters as indicated in C. GI = gastrointestinal; ILD = interstitial lung disease; DL co = diffusing capacity for carbon monoxide; DU = digital ulcer.