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. 2019 Jul 11;58(37):13030–13034. doi: 10.1002/anie.201906462

Scheme 2.

Scheme 2

Scope of the reaction the reaction with respect to the aryl chloride: Feed 1: 1 (2 mmol, 1.0 equiv), Fe(acac)3 (0.04 mmol), THF 5 mL; feed 2: 2 b (1.5 equiv), SIPr⋅HCl (0.08 mmol); 25 °C, residence time: 5 min, 24 W blue LEDs. Yields were determined by GC/LC; yields for the isolated products are reported in brackets. [a] Residence time: 2 min. [b] Fe(acac)3: 5 mol %, SIPr⋅HCl: 10 mol %. [c] Grignard reagent: 2.5 equivalents. [d] Residence time: 15 min. [e] Residence time: 1 min. [f] Residence time: 20 min. Scope of the reaction with respect to the Grignard reagent: Feed 1: 1 (2 mmol, 1.0 equiv), Fe(acac)3 (5 mol %); feed 2: 2 (1.5 equiv), SIPr⋅HCl (15 mol %), 25 °C, residence time: 20 min. [g] Fe(acac)3: 2 mol %, SIPr⋅HCl: 4 mol %. [h] [h] Fe(acac)3: 10 mol %, SIPr⋅HCl: 30 mol %, in batch with 34 W blue LED irradiation at 45 °C for 4 h. [i] 40 °C. [j] iPrMgBr (0.3 equiv) was added to feed 2. [k] Substrate 2 d: 2.0 equivalents.