Figure 3.

Effects of short‐term administration of SCO‐792 on FGF21 levels in DIO mice. A, Total food intake. B, body weight change. C, liver Fgf21 mRNA levels; and D, plasma FGF21 levels. DIO mice were treated with SCO‐792 (60 mg/kg) for 3 days. Pair‐fed group was fed the same amount of food consumed by the SCO‐792 group. SCO‐792 increased liver and circulating FGF21 levels. Data are expressed as mean ± SD (n = 5). ^a P ≤ .01 vs vehicle by Dunnett's test