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. 2019 Jul 2;21(10):2228–2239. doi: 10.1111/dom.13799

Figure 5.

Figure 5

Effects of repeated administration of SCO‐792 on insulin sensitivity in ob/ob mice. ob/ob mice were treated with either SCO‐792 (0.01% added to the diet) or vehicle alone for 6 days. A, Total food intake and B, body weight change; C, plasma glucose and D, insulin at end of study. E, After 6 days of dosing, mice were fasted overnight and hyperinsulinaemic‐euglycaemic clamp was performed. F, Glucose infusion rate during hyperinsulinaemic‐euglycaemic clamp. G, Plasma glucose levels maintained at c. 150 mg/dL during clamp procedure. H, Averaged glucose infusion rate; I, hepatic glucose production; and J, glucose disposal rate during steady state. Glucose uptake in K, muscle, L, liver and M, fat at end of clamp procedure. Data are expressed as mean ± SD (n = 14 and n = 16 for vehicle and SCO‐792, respectively). a P ≤ .01 vs vehicle by Student's t‐test. b P ≤ .05 vs vehicle by Aspin‐Welch test. c P ≤ .01 vs vehicle by Aspin‐Welch test