Table 1.

Inclusion and exclusion criteria

Inclusion Criteria

Exclusion Criteria

Willing to sign informed consent Age 18 to 80 Classic TN according to ICHD‐3b Unsatisfactory effect, intolerable side effects or contraindications of one of the following: ○Carbamazepine ○Oxcarbazepine And at least one of the following drugs: ○Gabapentin ○Pregabalin ○Baclofen ○Lamotrigine ○Phenytoin

Microvascular decompression is considered a better therapeutic choice Secondary TN Systemic or local disease that can interfere with the treatment Bilateral TN Reduced capacity to give informed consent Psychiatric condition preventing full participation Pregnancy or nursing Inability to use appropriate contraceptives in fertile women Abuse of drugs, including alcohol Anatomic anomalies that can hinder or impede treatment Hypersensitivity to local anesthetics, adrenalin or BTA or concomitant treatment with drugs that might interact with BTA

BTA = botulinum toxin type A; ICHD‐3b = International Classification of Headache Disorders, 3 beta edition; TN = trigeminal neuralgia.