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Serial maximum intensity projection (MIP) positron emission tomography (PET) images of mice injected with 52Mn‐DOTA‐TRC105 and 52MnCl2. Significant thyroid accumulation in the 52MnCl2 images contrasting the lack of uptake in the 52Mn‐DOTA‐TRC105 images indicates highly stable DOTA chelation of 52Mn2+ even at late time points. H, heart; K, kidneys; L, liver; T, tumour; Th, thyroid. Reprinted with permission from Graves et al21
