Table 4.
Contrast agents based on Gd and Mn and their physicochemical properties
| Contrast Agent | Longitudinal Relaxivity r1, 37°C, 20 MHz [mmol−1s−1] | Stability Constant logKML a | Ref |
|---|---|---|---|
| Gd‐DOTA (Dotarem) | 3.83 | 24.7 | 56, 57, 58 |
| Gd‐DTPA (Magnevist) | 4.02 | 22.5 | 25 |
| Mn‐DPDP (Teslascan) | 2.80 | 11.6 | 59 |
| Mn‐CDTA | 2.75 | 14.3 | 28 |
| Mn‐PyC3A | 2.10 | 14.1 | 60 |
| Mn‐DOTA | – | 19.9 | 60 |
| Mn‐DO3A | 1.30 | 19.4 | 27 |
a
KML = Equilibrium stability constant: [ML]/[M]*[L] with [ML] complex concentration; [M] metal ion concentration; [L] ligand concentration, in equilibrium.