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. 2019 Aug 28;62(10):656–672. doi: 10.1002/jlcr.3750

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© 2019 The Authors Journal of Labelled Compounds and Radiopharmaceuticals Published by John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Exendin‐4 in theranostics of insulinoma. Exendin‐4 can be used for diagnosis of GLP‐1 receptor (GLP‐1R) expressing tumor cells upon conjugation with 1) a radionuclide and preoperative SPECT or PET imaging or intraoperative detection with a gamma probe or 2) a fluorescent dye (FD) and intraoperative imaging with a near‐infrared (NIR) light camera. The same molecule can be used for therapy of GLP‐1R expressing tumor cells upon conjugation with 1) a therapeutic radionuclide for peptide receptor radionuclide therapy (PRRT) and 2) a photosensitizer (PS) for targeted photodynamic therapy (tPDT).