Table 1.
Overview of preclinical SPECT tracers and their characteristics
| Author + Year | Compound | Tumor Model | Peptide Dose | Activity Dose | Tumor Uptake | Kidney Uptake |
|---|---|---|---|---|---|---|
| Indium‐111 | ||||||
| Wild et al. 2006 | [Lys40(Ahx‐[111In]In‐DTPA)NH2]exendin‐4 | RipTag2 and C57BL/6J RipTag2 |
10 ng (BD) 50 pmol (Im) |
185‐370 kBq (BD) 37 MBq (Im) |
287 ± 62 %IA/g (4 h) | 209 ± 35 %IA/g (4 h) |
| Wild et al. 2010 | [Lys40(Ahx‐DTPA‐[111In]In)NH2]exendin‐4 | RipTag2 | 10 pmol | 70‐110 kBq | 213 ± 75 %IA/g (4 h) | 243 ± 17 %IA/g (4 h) |
| Brom et al. 2012 | [Lys40(Ahx‐[111In]In‐DTPA)NH2]exendin‐3 | INS‐1 | 20 pmol | 370 kBq |
25.0 ± 6.0 %ID/g (30 min) 26.5 ± 8.9 %ID/g (4 h) |
150.7 ± 14.9 %ID/g (30 min) 188.8 ± 14.4 %ID/g (4 h) |
| Brom et al. 2012 | [Lys40(Ahx‐[111In]In‐DTPA)NH2]exendin‐4 | INS‐1 | 20 pmol | 370 kBq |
30.7 ± 6.1 %ID/g (30 min) 41.9 ± 7.2 %ID/g (4 h) |
150.9 ± 9.6 %ID/g (30 min) 173.6 ± 24.3 %ID/g (4 h) |
| Brom et al. 2012 | [Lys40(Ahx‐[111In]In‐DTPA)NH2]exendin(9‐39) | INS‐1 | 20 pmol | 370 kBq |
3.2 ± 0.7 %ID/g (30 min) 0.71 ± 0.2 %ID/g (4 h) |
65.7 ± 6.1 %ID/g (30 min) 70.7 ± 4.0 %ID/g (4 h) |
| Bauman et al. 2015 | [Lys40‐(AHX‐DTPA‐[111In]In)NH2]exendin‐4 | RIN‐m5f | 10 pmol, 52 ng | 385 kBq |
14.74 ± 5.91 %ID/g (1 h) 15.56 ± 5.32 %ID/g (4 h) 9.31 ± 2.35 %ID/g (24 h) 3.47 ± 0.52 %ID/g (48 h) |
152.70 ± 24.86 %ID/g (1 h) 178.41 ± 33.66 %ID/g (4 h) 144.09 ± 20.94 %ID/g (24 h) 84.80 ± 19.26 %ID/g (48 h) |
| Kimura et al. 2017 | [Lys12([111In]In‐BnDTPA)]exendin‐9‐39 | INS‐1 |
1.5 ng 790 ng |
37 kBq/100 μL (BD) 19.9 MBq/220 μL (Im) |
7.83 ± 1.86 %ID/g (30 min) 1.87 ± 0.52 %ID/g (4 h) – |
193.6 ± 15.1 %ID/g (30 min) 180.9 ± 52.7 %ID/g (4 h) – |
| Technetium‐99m | ||||||
| Wild et al. 2010 | [Lys40(Ahx‐HYNIC‐[99mTc]Tc/EDDA)NH2]exendin‐4 | RipTag2 |
10 pmol (BD) – |
70‐110 kBq (BD) 37 MBq (Im) |
67 ± 13 %IA/g (30 min) 93.1 ± 19.9 %IA/g (4 h) – |
63 ± 10 %IA/g (30 min) 60 ± 12 %IA/g (4 h) – |
| Medina‐Garcia et al. 2015 | [Lys27([99mTc]Tc‐EDDA/HYNIC)]exendin(9‐39) | AR42J induced | – | 1.85 MBq | 2.41 ± 0.38 %ID/g (2 h) | 95.01 ± 1.95 %ID/g (2 h) |
Abbreviations: BD, biodistribution; Im, imaging; SPECT, single‐photon emission computed tomography.