Figure 10.

In vivo glucose injection experiments in three mice bearing TS/A tumor xenografts using adiabatic SL prepared acquisition at 7 T. Data acquired at different saturation pulse power levels and durations were compared and evaluated using Z_diff at 1.2 ppm (Z_diff = Z_post‐Z_pre). Bar plots of the average Z_diff calculated in ROI encompassing the whole tumor region for the experiments in (A) mouse 1, (B) mouse 2 and (C) mouse 3; (D) Z_diff images overlaid onto the T₂w anatomical image for mouse 1 showing the effect of different saturation power levels and duration times on the calculated glucoCEST contrast upon CESL acquisition. CESL acquisition with B₁ = 5 μT and t_sat = 0.5 s yielded an average Z_diff of 13.7 ± 0.98% in the three investigated mice. Error bars in (A‐C) show this determined standard deviation