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. 2019 Jun 24;34(8):1120–1127. doi: 10.1002/mds.27742

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© 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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The aged brain is capable of supporting survival of large numbers of grafted DA neurons and extensive graft‐derived neurite outgrowth. (A,D) DA graft in young rat; (B,E) DA graft in middle‐aged rat; and (C,F) DA graft in aged rat. (G) There are significantly more grafted TH⁺/DA neurons in the aged brain, (H) with significantly more TH⁺ fibers in the middle‐aged and aged striatum proximal to the graft compared to young striatum. Proximal: 0–850 μm from the graft border; distal: 850–1,700 μm from the graft border. Asterisks denote significant differences (P < 0.05) for indicated comparison. Images modified from Collier and colleagues.24