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. 2019 Jun 3;40(13):3900–3909. doi: 10.1002/hbm.24638

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© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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p‐value map of AAL regions with significant different T1‐w/T2‐w ratios between AD and NC subjects. Higher T1‐w/T2‐w ratio values were found widespread in AD, in particular in AD‐related regions: superior and middle frontal gyrus; inferior frontal gyrus pars opercularis and triangularis; rolandic operculum; insula; anterior, mid and posterior cingulate gyrus; calcarine; cuneus; middle occipital gyrus; superior and inferior parietal lobule; supramarginal gyrus; angular gyrus; precuneus; superior and middle temporal gyrus. All analyses were adjusted for multiple comparisons showing a moderate (Yellow p < .0005) to highly (Red p < .000000001) significance scale. AAL, automated anatomical labeling; AD, Alzheimer's disease; NC, normal cognition [Color figure can be viewed at http://wileyonlinelibrary.com]