Figure 2.

(A and B) Mean population fitness $\overline{W}$ and inbreeding depression δ versus selfing fraction $r_s$, when the genome has $L_A=1000$ additive and $L_R=5000$ partially recessive loci. The dominance coefficient of partially recessive alleles is $h=0.1$ in (A), and $h=0.02$ in (B). Solid lines represent predictions of the ILEC approximation, triangles depict results from simulations of $N=10,000$ individuals. (C and D) Comparison of simulation results (triangles) and ILEC predictions (lines) for the probability distributions of genetic load G (defined as negative log fitness $G=-\ln (W)$) in the source population. The plots show load distributions for three different selfing fractions: $r_s=0.2,0.5,0.8$, and for two different dominance values of the recessive allele: $h=0.1$ (C) and $h=0.02$ (D). The distribution of G is bimodal due to significantly higher number of homozygous deleterious, recessive alleles in the genomes of selfed versus outcrossed offspring. Mutation rates per locus are ${\mu }_A={\mu }_R={10}^{-4}$, selection against partially recessive deleterious alleles (in the homozygous state) is $s=0.05$ and the strength of selection per additive allele is ${\stackrel{\sim }{s}}_0={\beta }_0\alpha =0.005$.