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. 2019 Aug 7;25(50):11620–11624. doi: 10.1002/chem.201902160

Table 1.

Optimization of the reaction conditions.[a]

graphic file with name CHEM-25-11620-g006.jpg
Entry Lewis acid [mol %] 3 a [equiv] Solvent Yield [%]
1 AlCl3 20 1.3 DCE 0
2 MgI2 20 1.3 DCE 0
3 Sc(OTf)3 20 1.3 DCE 0
4 Sn(OTf)2 20 1.3 DCE 69
5 Y(OTf)3 20 1.3 DCE 0
6 Sn(OTf)2 5 1.3 DCE 0
7 Sn(OTf)2 10 1.3 DCE 86
8 Sn(OTf)2 10 1.3 CH2Cl2 29
9 Sn(OTf)2 10 1.3 dioxane 0
10 Sn(OTf)2 10 1.7 DCE 93
11 Sn(OTf)2 10 2.3 DCE 72
12[b] Sn(OTf)2 10 1.3 DCE 35

[a] Reaction conditions: 1 (165 μmol), Lewis acid, solvent (1.5 mL), 2 a (150 μmol), 3 a, 25 °C, 10 h, Ar atmosphere; yields represent isolated and purified products; [b] The corresponding phthalimide derivative was used instead of 3 a.