Table 3.
Results of mediation model; association between adverse childhood experiences and self‐harm via inflammatory markers interleukin‐6 and C‐reactive protein (imputed data N = 4,308)
| Model | Direct effect | Indirect effect via IL‐6 and CRP | Total effect | ||||||
|---|---|---|---|---|---|---|---|---|---|
| RR | 95% CI | p | RR | 95% CI | p | RR | 95% CI | p | |
| Main analysis | |||||||||
| Self‐harm at age 16 | 1.11 | 1.05, 1.17 | <0.001 | 1.00 | 1.00, 1.00 | 0.380 | 1.11 | 1.05, 1.18 | <0.001 |
| Sensitivity analyses | |||||||||
| Self‐harm at age 21 | 1.12 | 1.06, 1.18 | <0.001 | 1.00 | 1.00, 1.01 | 0.617 | 1.12 | 1.06, 1.18 | <0.001 |
| Multiple self‐harm at age 16 | 1.10 | 1.03, 1.17 | 0.007 | 1.00 | 1.00, 1.00 | 0.668 | 1.10 | 1.03, 1.17 | 0.007 |
| Suicide attempt at age 16 | 1.22 | 1.11, 1.33 | <0.001 | 1.00 | 1.00, 1.01 | 0.806 | 1.22 | 1.11, 1.33 | <0.001 |
| Excluding those with psychiatric disorder at age 15 (n = 4,138) | 1.11 | 1.05, 1.17 | <0.001 | 1.00 | 1.00, 1.01 | 0.313 | 1.11 | 1.05, 1.17 | <0.001 |
| Excluding those with CRP values of >10 mg/L excluded (n = 4,278) | 1.11 | 1.05, 1.17 | <0.001 | 1.00 | 1.00, 1.00 | 0.318 | 1.11 | 1.05, 1.18 | <0.001 |
All models adjusted for BMI, internalising and externalising problems as intermediate confounders, and child sex, maternal smoking during pregnancy, income, maternal education and housing tenure as covariates; CRP, C‐reactive protein. Fifty imputed data sets generated. RR, relative risk; CI, confidence interval.