. 2019 Jun 3;21(8):1925–1934. doi: 10.1111/dom.13753

Table 2.

Characteristics of the four profiles: Outcome = HbA1c change

Profile		Learning dataset					Validation dataset
		N (%)	Class effect (within the profile)		Class benefit (within vs. without the profile)		N (%)	Class effect (within the profile)			Class benefit (within vs. without the profile)
		N (%)	aΔ	P value	aΔ	P value	N (%)	aΔ	P value	BH P value	aΔ	P value	BH P value
A. Hyperlipidaemia	No	724 (20)	−0.01	0.72	0.00	0.83	296 (19)	0.00	0.92	0.99	−0.01	0.77	0.83
eGFR	≥79 mL/min/1.73 m²	724 (20)	−0.01	0.72	0.00	0.83	296 (19)	0.00	0.92	0.99	−0.01	0.77	0.83
B. eGFR	≥79 mL/min/1.73 m²	556 (15)	0.02	0.49	0.02	0.34	238 (15)	0.03	0.30	0.99	0.03	0.38	0.83
Duration of diabetes	≤1.2 years	556 (15)	0.02	0.49	0.02	0.34	238 (15)	0.03	0.30	0.99	0.03	0.38	0.83
C. eGFR	≥75 mL/min/1.73 m²	430 (12)	−0.02	0.26	−0.02	0.27	198 (13)	−0.01	0.77	0.99	−0.02	0.50	0.83
Antithrombotic agents	Yes	430 (12)	−0.02	0.26	−0.02	0.27	198 (13)	−0.01	0.77	0.99	−0.02	0.50	0.83
D. Haemoglobin	≤13.4 g/dL	384 (10)	0.01	0.79	0.01	0.78	176 (11)	0.01	0.75	0.99	0.01	0.74	0.83
LDL cholesterol	≥95.1 mg/dL	384 (10)	0.01	0.79	0.01	0.78	176 (11)	0.01	0.75	0.99	0.01	0.74	0.83

Abbreviations: aΔ, adjusted mean difference; BH, Benjamini–Hochberg; eGFR, estimated glomerular filtration rate.