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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Annu Rev Biophys. 2019 Apr 5;48:465–494. doi: 10.1146/annurev-biophys-052118-115534

Figure 2.

Figure 2.

Carbohydrate-lectin interactions in receptor oligomerization. (LEFT) The extracellular domain of transmembrane receptors (Yellow) can be modified with monosaccharides and polysaccharides (Magenta) to create binding sites for the carbohydrate recognition domain (CRD) of Galectin-3 (Green). (RIGHT) Saccharide-modified transmembrane receptors are bound by the CRD of Galectin-3. The intrinsically disordered region (IDR) of Galectin-3 self-associates with other IDRs of neighboring Galectin-3 molecules to form a multivalent network of modified transmembrane receptors and Galectin-3.