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. 2019 Jul 16;91(10):1837–1844. doi: 10.1002/jmv.25533

Figure 3.

Figure 3

Natural history of liver disease over 40 years in hypothetical cohorts of asymptomatic carriers at age 40. A, Males: At age 50, asymptomatic carrier status accounted for 25.4% of patients, chronic hepatitis for 58.4%, cirrhosis for 14.4%, and HCC for 2.2%. At age 60, asymptomatic carrier status accounted for 4.6% of patients, chronic hepatitis for 48.0%, cirrhosis for 32.5%, and HCC for 14.9%. At age 70, asymptomatic carrier status accounted for 0.9% of patients, chronic hepatitis for 21.9%, cirrhosis for 41.1%, and HCC for 36.1%. At age 80, asymptomatic carrier status accounted for 0.1% of patients, chronic hepatitis for 6.6%, cirrhosis for 35.3%, and HCC for 58.0%. B, Females: At age 50, asymptomatic carrier status accounted for 19.7% of patients, chronic hepatitis for 66.5%, cirrhosis for 13.8%, and HCC for 0.0%. At age 60, asymptomatic carrier status accounted for 7.0% of patients, chronic hepatitis for 47.9%, cirrhosis for 42.0%, and HCC for 3.1%. At age 70, asymptomatic carrier status accounted for 2.1% of patients, chronic hepatitis for 20.9%, cirrhosis for 58.8%, and HCC for 18.2%. At age 80, asymptomatic carrier status accounted for 0.7% of patients, chronic hepatitis for 10.1%, cirrhosis for 52.2%, and HCC for 37.0%. HCC, hepatocellular carcinoma