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. 2019 Jul 16;91(10):1837–1844. doi: 10.1002/jmv.25533

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© 2019 The Authors. Journal of Medical Virology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Natural history of liver disease over 40 years in hypothetical cohorts of patients with chronic hepatitis at age 40. A, Males: At age 50, chronic hepatitis accounted for 63.7% of patients, cirrhosis for 29.0%, and HCC for 7.3%. At age 60, chronic hepatitis accounted for 37.7% of patients, cirrhosis for 38.0%, and HCC for 24.3%. At age 70, chronic hepatitis accounted for 15.9% of patients, cirrhosis for 38.6%, and HCC for 45.5%. At age 80, chronic hepatitis accounted for 4.6% of patients, cirrhosis for 30.7%, and HCC for 64.7%. B, Females: At age 50, chronic hepatitis accounted for 84.6% of patients, cirrhosis for 15.4%, and HCC for 0.0%. At age 60, chronic hepatitis accounted for 49.9% of patients, cirrhosis for 46.5%, and HCC for 3.6%. At age 70, chronic hepatitis accounted for 19.7% of patients, cirrhosis for 60.8%, and HCC for 19.5%. At age 80, chronic hepatitis accounted for 9.0% of patients, cirrhosis for 52.4%, and HCC for 38.6%. HCC, hepatocellular carcinoma