Table 3.
Patch test results obtained with the baseline series with crude and age‐standardized and sex‐standardized prevalences of positive reactions on day (D) 3 and/or D7 accompanied by 95% confidence intervals (CIs)
| New positive D7 reactions | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total patch tested patients (n = 3292) | Total crude positives on D3 and/or D7 (n = 1653) | Total age‐standardized and sex‐standardized positives on D3 and/or D7 | Total | Reaction type at D3 reading (n) | Reaction strength on D7 (n) | Proportion of total positive reactions | ||||||||||
| Haptens | Concentration (μg/cm2) | N | n | % | n | % | 95% CI | n | % | − | ? | IR | + | ++ | +++ | % |
| Nickel sulfate | 200 | 3172 | 607 | 19.1 | 424 | 14.5 | 12.2‐14.6 | 104 | 3.3 | 64 | 22 | 18a | 96 | 8 | 0 | 17.1 |
| Lanolin alcohols | 1000 | 3218 | 44 | 1.4 | 41 | 1.4 | 0.9‐1.7 | 10 | 0.3 | 4 | 6 | 0 | 9 | 1 | 0 | 22.7 |
| Neomycin sulfate | 230 | 3209 | 27 | 0.8 | 25 | 0.9 | 0.5‐1.1 | 22 | 0.7 | 21 | 1 | 0 | 20 | 2 | 0 | 81.5 |
| Potassium dichromate | 23 | 3206 | 122 | 3.8 | 112 | 3.8 | 2.9‐4.1 | 18 | 0.6 | 11 | 7 | 0 | 16 | 2 | 0 | 14.8 |
| Caine mix | 630 | 3217 | 34 | 1.1 | 27 | 0.9 | 0.5‐1.2 | 9 | 0.3 | 9 | 0 | 0 | 7 | 2 | 0 | 26.5 |
| Fragrance mix I | 430 | 3216 | 138 | 4.3 | 115 | 3.9 | 2.9‐4.2 | 21 | 0.7 | 16 | 4 | 1 | 21 | 0 | 0 | 15.2 |
| Colophonium | 850 | 3204 | 110 | 3.4 | 95 | 3.2 | 2.4‐3.6 | 17 | 0.5 | 15 | 2 | 0 | 15 | 2 | 0 | 15.5 |
| Epoxy resin | 50 | 3216 | 91 | 2.8 | 92 | 3.1 | 2.3‐3.4 | 28 | 0.9 | 20 | 7 | 1 | 24 | 3 | 1 | 30.8 |
| Quinoline mix | 190 | 3218 | 7 | 0.2 | 9 | 0.3 | 0.1‐0.5 | 2 | 0.1 | 2 | 0 | 0 | 1 | 1 | 0 | 28.6 |
| Myroxylon pereirae (balsam of Peru) | 800 | 3217 | 89 | 2.8 | 59 | 2.0 | 1.4‐2.3 | 19 | 0.6 | 15 | 3 | 1 | 19 | 0 | 0 | 21.3 |
| Ethylenediamine dihydrochloride | 50 | 3218 | 29 | 0.9 | 34 | 1.2 | 0.7‐1.4 | 3 | 0.1 | 1 | 1 | 1a | 3 | 0 | 0 | 10.3 |
| Cobalt chloride | 20 | 3211 | 175 | 5.5 | 160 | 5.4 | 4.2‐5.7 | 25 | 0.8 | 17 | 6 | 2a | 23 | 2 | 0 | 14.3 |
| PTBP‐FR | 40 | 3207 | 92 | 2.9 | 78 | 2.7 | 1.9‐3.0 | 17 | 0.5 | 11 | 6 | 0 | 16 | 1 | 0 | 18.5 |
| Parabens mix | 1000 | 3218 | 9 | 0.3 | 9 | 0.3 | 0.1‐0.5 | 2 | 0.1 | 1 | 1 | 0 | 2 | 0 | 0 | 22.2 |
| Carba mix | 250 | 3217 | 117 | 3.6 | 125 | 4.2 | 3.2‐4.6 | 4 | 0.1 | 4 | 0 | 0 | 4 | 0 | 0 | 3.4 |
| Black rubber mix | 75 | 3218 | 34 | 1.1 | 28 | 0.9 | 0.5‐1.2 | 7 | 0.2 | 6 | 1 | 0 | 7 | 0 | 0 | 20.6 |
| MCI/MI | 4 | 3219 | 331 | 10.3 | 312 | 10.6 | 8.7‐10.7 | 23 | 0.7 | 18 | 5 | 0 | 20 | 3 | 0 | 6.9 |
| Quaternium‐15 | 100 | 3218 | 61 | 1.9 | 45 | 1.5 | 1.0–1.8 | 15 | 0.5 | 12 | 3 | 0 | 14 | 1 | 0 | 24.6 |
| Mercaptobenzothiazole | 75 | 3217 | 34 | 1.1 | 34 | 1.2 | 0.7‐1.4 | 1 | 0.0 | 1 | 0 | 0 | 1 | 0 | 0 | 2.9 |
| p‐Phenylenediamine | 90 | 3210 | 105 | 3.3 | 83 | 2.8 | 2.0–3.1 | 13 | 0.4 | 7 | 6 | 0 | 11 | 2 | 0 | 12.4 |
| Formaldehyde | 180 | 3218 | 51 | 1.6 | 38 | 1.3 | 0.8‐1.6 | 13 | 0.4 | 8 | 5 | 0 | 11 | 2 | 0 | 25.5 |
| Mercapto mix | 75 | 3217 | 43 | 1.3 | 46 | 1.6 | 1.0‐1.8 | 2 | 0.1 | 1 | 1 | 0 | 2 | 0 | 0 | 4.7 |
| Thiomersal | 8 | 3209 | 40 | 1.2 | 30 | 1.0 | 0.6‐1.3 | 9 | 0.3 | 7 | 2 | 0 | 9 | 0 | 0 | 22.5 |
| Thiuram mix | 25 | 3207 | 76 | 2.4 | 73 | 2.5 | 1.8‐2.8 | 9 | 0.3 | 6 | 3 | 0 | 9 | 0 | 0 | 11.8 |
| MI | 0.2% aq. | 466 | 32 | 6.9 | 31 | 7.2 | 4.4‐8.9 | 3 | 0.6 | 2 | 1 | 0 | 2 | 1 | 0 | 9.4 |
| Fragrance mix II | 14% pet. | 3275 | 246 | 7.5 | 181 | 6.0 | 4.7‐6.3 | 33 | 1.0 | 14 | 18 | 1 | 33 | 0 | 0 | 13.4 |
| HICC | 5% pet. | 3242 | 98 | 3.0 | 72 | 2.4 | 1.7‐2.7 | 22 | 0.7 | 17 | 5 | 0 | 22 | 0 | 0 | 22.4 |
| Sesquiterpene lactone mix | 0.1% pet. | 3277 | 43 | 1.3 | 40 | 1.3 | 0.8‐1.6 | 13 | 0.4 | 10 | 3 | 0 | 11 | 2 | 0 | 30.2 |
| Parthenolide | 0.1% pet. | 3233 | 42 | 1.3 | 37 | 1.2 | 0.8‐1.5 | 14 | 0.4 | 12 | 2 | 0 | 9 | 5 | 0 | 33.3 |
| MDBGN | 0.5% pet. | 3247 | 127 | 3.9 | 134 | 4.5 | 3.4‐4.8 | 17 | 0.5 | 7 | 10 | 0 | 17 | 0 | 0 | 13.4 |
| Budesonide | 0.1% pet. | 3276 | 26 | 0.8 | 22 | 0.7 | 0.4‐1.0 | 11 | 0.3 | 7 | 4 | 0 | 9 | 2 | 0 | 42.3 |
| Tixocortol‐21‐pivalate | 0.1% pet. | 3277 | 27 | 0.8 | 29 | 1.0 | 0.6‐1.2 | 4 | 0.1 | 2 | 2 | 0 | 4 | 0 | 0 | 14.8 |
| Hydrocortisone‐17‐butyrate | 1% eth. | 3250 | 14 | 0.4 | 12 | 0.4 | 0.2‐0.6 | 4 | 0.1 | 2 | 2 | 0 | 4 | 0 | 0 | 28.6 |
| Textile dye mix | 6.6% pet. | 991 | 52 | 5.2 | 47 | 5.0 | 3.4‐6.1 | 12 | 1.2 | 8 | 4 | 0 | 11 | 1 | 0 | 23.1 |
| Disperse Blue 106 | 1% pet. | 3250 | 31 | 1.0 | 27 | 0.9 | 0.5‐1.1 | 9 | 0.3 | 8 | 1 | 0 | 9 | 0 | 0 | 29.0 |
| Disperse Blue 124 | 1% pet. | 3274 | 27 | 0.8 | 23 | 0.8 | 0.4‐1.0 | 10 | 0.3 | 10 | 0 | 0 | 10 | 0 | 0 | 37.0 |
| Toluene‐2,5‐diamine | 1% pet. | 2333 | 48 | 2.1 | 35 | 1.6 | 1.0‐2.0 | 9 | 0.4 | 7 | 2 | 0 | 8 | 1 | 0 | 18.8 |
| Sodium disulfite | 1% pet. | 395 | 35 | 8.9 | 35 | 9.6 | 6.1‐11.7 | 6 | 1.5 | 2 | 4 | 0 | 6 | 0 | 0 | 17.1 |
| 2‐Bromo‐2‐nitropropane‐1,3‐diol | 0.5% pet. | 3250 | 22 | 0.7 | 22 | 0.7 | 0.4‐1.0 | 11 | 0.3 | 7 | 4 | 0 | 11 | 0 | 0 | 50.0 |
| Diazolidinyl urea | 2% pet. | 3250 | 29 | 0.9 | 21 | 0.7 | 0.4‐0.9 | 12 | 0.4 | 9 | 3 | 0 | 11 | 1 | 0 | 41.4 |
| Imidiazolidinyl urea | 2% pet. | 3250 | 26 | 0.8 | 20 | 0.7 | 0.3‐0.9 | 7 | 0.2 | 3 | 4 | 0 | 6 | 1 | 0 | 26.9 |
| 1,2‐Benzisothiazolin‐3‐one | 0.05% pet. | 3230 | 21 | 0.7 | 25 | 0.8 | 0.5‐1.1 | 2 | 0.1 | 0 | 2 | 0 | 2 | 0 | 0 | 9.5 |
| Amerchol L 101 | 50% pet. | 606 | 19 | 3.1 | 14 | 2.5 | 1.1‐3.5 | 2 | 0.3 | 1 | 1 | 0 | 2 | 0 | 0 | 10.5 |
Abbreviations: HICC, hydroxylisohexyl 3‐cyclohexene carboxaldehyde (Lyral); IR, irritant reaction; MCI, methylchloroisothiazolinone; MDBGN, methyldibromo glutaronitrile (dibromodicyanobutane); MI, methylisothiazolinone; PTBP‐FR, p‐tert‐butylphenol formaldehyde resin.
a
Follicular reactions: nickel sulfate, n = 18; ethylenediamine dihydrochloride, n = 1; cobalt chloride, n = 2.