Table 2.
Signaling pathway enrichment analysis of DEGs in multiple myeloma
| Pathway | Name | Gene count | p value | Genes |
|---|---|---|---|---|
| Upregulated DEG | ||||
| Reactome:R‐HSA‐72689 | Formation of a pool of free 40S subunits | 7 | 1.52 × 10−7 | RPS19;RPL32;EIF3K;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐156827 | L13a‐mediated translational silencing of Ceruloplasmin expression | 7 | 1.14 × 10−6 | RPS19;RPL32;EIF3K;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7 | 1.54 × 10−6 | RPS19;RPL32;EIF3K;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐72764 | Eukaryotic Translation Termination | 6 | 3.13 × 10−6 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐1799339 | SRP‐dependent cotranslational protein targeting to membrane | 6 | 4.64 × 10−6 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐975956 | Nonsense‐mediated decay (NMD) independent of the exon junction complex (EJC) | 6 | 5.10 × 10−6 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐156902 | Peptide chain elongation | 6 | 5.35 × 10−6 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐192823 | Viral mRNA Translation | 6 | 8.71 × 10−6 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐2408557 | Selenocysteine synthesis | 6 | 1.26 × 10−5 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| Reactome:R‐HSA‐156842 | Eukaryotic translation elongation | 6 | 2.45 × 10−5 | RPS19;RPL32;RPL24;RPLP2;RPL35;UBA52 |
| KEGG Pathway: hsa03010 | Ribosome | 6 | 2.73 × 10−5 | RPS19, RPL32, RPL35, RPLP2, RPL24, UBA52 |
| Downregulated DEG | ||||
| Reactome:R‐HSA‐381340 | Transcriptional regulation of white adipocyte differentiation | 6 | 6.50 × 10−5 | FABP4;LPL;CD36 |
| KEGG Pathway: hsa04662 | B cell receptor signaling pathway | 6 | 1.05 × 10−4 | CR2, RASGRP3, CD81, CD79A, BLNK, SYK |
| Reactome:R‐HSA‐114608 | Platelet degranulation | 6 | 2.34 × 10−4 | TF;SERPING1;CD9;CTSW;CD36;A2M |
| Reactome:R‐HSA‐76005 | Response to elevated platelet cytosolic Ca2+ | 6 | 3.05 × 10−4 | TF;SERPING1;CD9;CTSW;CD36;A2M |
| Reactome:R‐HSA‐2022870 | Chondroitin sulfate biosynthesis | 3 | 5.51 × 10−4 | CSGALNACT1;VCAN;DCN |
| Reactome:R‐HSA‐8957275 | Posttranslational protein phosphorylation | 5 | 6.44 × 10−4 | VCAN;TF;IGFBP5;CHRDL1;FBN1 |
| Reactome:R‐HSA‐381426 | Regulation of insulin‐like growth factor (IGF) transport and uptake by insulin‐like growth factor binding proteins (IGFBPs) | 5 | 1.3 × 10−3 | VCAN;TF;IGFBP5;CHRDL1;FBN1 |
| Reactome:R‐HSA‐3595174 | Defective CHST14 causes EDS, musculocontractural type | 2 | 1.51 × 10−3 | VCAN;DCN |
| Reactome:R‐HSA‐3595172 | Defective CHST3 causes SEDCJD | 2 | 1.51 × 10−3 | VCAN;DCN |
| Reactome:R‐HSA‐3595177 | Defective CHSY1 causes TPBS | 2 | 1.86 × 10−3 | VCAN;DCN |
| Reactome:R‐HSA‐977606 | Regulation of complement cascade | 5 | 1.88 × 10−3 | CR2;IGKC;C1S;CD81;SERPING1 |
Abbreviation: CR2, Component 3d receptor 2; DEGs, differentially expressed genes.