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. 2019 Jul 22;12(16):3801–3807. doi: 10.1002/cssc.201901499

Table 3.

Decarboxylative N‐alkylation of amino acids with secondary and long‐chain alcohols.[a] Inline graphic

Entry Product Yield[b] [%]
1 3 aq graphic file with name CSSC-12-3801-g026.jpg 57
2 3 ar graphic file with name CSSC-12-3801-g027.jpg 76[c]
3 3 as graphic file with name CSSC-12-3801-g028.jpg 0
4 3 at graphic file with name CSSC-12-3801-g029.jpg 49
5 3 au graphic file with name CSSC-12-3801-g030.jpg 62
6 3 av graphic file with name CSSC-12-3801-g031.jpg 42[c]
7 3 aw graphic file with name CSSC-12-3801-g032.jpg 81[d]
8 3 ax graphic file with name CSSC-12-3801-g033.jpg 51[c]
9 3 ay graphic file with name CSSC-12-3801-g034.jpg 54
10 3 by graphic file with name CSSC-12-3801-g035.jpg 55

[a] General reaction conditions: 0.5 mmol of 1, 1 mmol of 2, 1 mol % C1, 2 mL toluene, 24 h, 120 °C, under argon. [b] Isolated yields. [c] Yields are based on 1H NMR spectroscopy, using 1,3,5‐trimethoxybenzene as an internal standard. [d] Reduced double bond in the product (note: 2 equiv. of alcohol used).