Figure 3.

Role of Wnt/β‐catenin signaling and TCF7L2 in neurogenesis and gliogenesis in the neocortex. The process of developmental neurogenesis and gliogenesis in the neocortex is opposite to the temporal gradient of Wnt signaling (shown in yellow). Genetic manipulation to downregulate Wnt/β‐catenin signaling causes premature neurogenic divisions of uncommitted progenitors (RG) and a shorter time of neurogenesis as a consequence of precocious astrogenesis. Wnt/β‐catenin signaling inhibits oligodendrocyte precursor cell (OPC) differentiation. This is antagonized by interactions between TCF7L2 and the Kaiso co‐repressor. TCF7L2 interacts with the SOX10 to promote the further differentiation of iOL into mOL in a β‐catenin‐independent manner. Steps in this process that were shown to be activated or inhibited by Wnt/β‐catenin signaling or TCF7L2 are indicated in green with arrows and red bar‐headed lines, respectively. GP, glial progenitor