Table 2.
Colonic biopsy 5‐HIAA, 5‐HT, 5‐HIAA/5‐HT, and 5‐HT release during 30 min incubation for IBS‐D patients and healthy volunteers
| Variable | Patients (n = 57) | Healthy volunteers (n = 21) | P value |
|---|---|---|---|
| biopsy 5‐HIAA (pmol/mg protein) | 2.1 (1.2‐4.2) | 1.1 (0.4‐1.5) | .0001 |
| biopsy 5‐HIAA/5‐HT | 0.06 (0.03‐0.16) | 0.02 (0.02‐0.05) | .0038 |
| biopsy 5‐HT (pmol/mg protein) | 31.2 (20.1‐46.0) | 39.1 (16.5‐46.7) | .9288 |
| biopsy 5‐HT release in 30mins (pmol/mg wet weight) | 17.2 (13.5‐23.1) | 23.8 (13.8‐44.2) | .078 |
| Biopsy 5‐HT release in 30mins/ Biopsy 5‐HT content | 0.8 (0.3‐1.1) | 0.8 (0.2‐2.2) | .851 |
Data are median (IQR). P values obtained from Mann‐Whitney tests.