Figure 9.

Gene expressions after chondrogenic differentiation of pRRL‐infected MSCs from two donors. The gene expressions of all chondrogenic marker genes investigated for MSC C are notably lower than for MSC A although the experiments were conducted in parallel for three weeks. Markers for mature chondrocytes: COL2A1 (collagen type II alpha I), COMP (cartilage oligomeric protein), ACAN (aggrecan); marker of early chondrogenesis: SOX9 (sex determining region Y‐box 9); marker for hypertrophic, mineralized chondrocytes: MMP13 (matrix metalloprotease 13), ALPL (Alkaline Phosphatase). Luc: control vector with luciferase and BDNF expression (vector with BDNF expression, either in the plasmid system with tdTomato as marker gene [pRRL] or with GFP as marker gene [pSIEW])