Table 3.
Correlation Analysis with Logistic Regression or Multiple Regression Model of Each Polyamine Metabolite, Disease Severity (H&Y or UPDRS‐III), and LED
| Compound Name | H&Y (normalized to LED) | UPDRS‐III (normalized to LED) | ||
|---|---|---|---|---|
| F a | p a | F b | p b | |
| DiAcSpd | 3.45 | 0.0096 | 4.28 | 0.04 |
| N1‐AcSpd | 0.77 | 0.546 | 0.169 | 0.681 |
| N8‐AcSpd | 3.08 | 0.0176 | 3.08 | 0.0808 |
| DiAcSpm | 3.73 | 0.0061 | 3.2 | 0.0755 |
| Spd | 1.31 | 0.27 | 1.46 | 0.229 |
| N1‐AcSpm | 1.22 | 0.303 | 0.576 | 0.449 |
| Spm | 1.62 | 0.172 | 0.0022 | 0.962 |
| Spm/Spd ratio | 0.156 | 0.96 | 1.15 | 0.285 |
a
Obtained by logistic regression analysis.
b
Obtained by multiple regression analysis.
DiAcSpd = N1,N8‐diacetylspermidine; DiAcSpm = N1,N12‐diacetylspermine; H&Y = Hoehn and Yahr stage; LED = L‐dopa equivalent dose; N1‐AcSpd = N1‐acetylspermidine; N1‐AcSpm = N1‐acetylspermine; N8‐AcSpd = N8‐acetylspermidine; Spd = spermidine; Spm = spermine; UPDRS‐III = Unified Parkinson's Disease Rating Scale motor section.