Table 4.
Correlation Analysis with Logistic Regression or Multiple Regression Model of Each Polyamine Metabolite, Disease Severity (H&Y or UPDRS‐III), and Age at Sampling
| Compound Name | H&Y (normalized by age at sampling) | UPDRS‐III (normalized by age at sampling) | ||
|---|---|---|---|---|
| F a | p a | F b | p b | |
| DiAcSpd | 3.18 | 0.015 | 5.85 | 0.0165 |
| N1‐AcSpd | 1.32 | 0.263 | 0.146 | 0.228 |
| N8‐AcSpd | 3.22 | 0.014 | 4.58 | 0.0337 |
| DiAcSpm | 2.94 | 0.0301 | 3.26 | 0.0725 |
| Spd | 1.45 | 0.219 | 1.37 | 0.244 |
| N1‐AcSpm | 1.41 | 0.233 | 0.258 | 0.612 |
| Spm | 1.79 | 0.132 | 0.730 | 0.394 |
| Spm/Spd ratio | 0.185 | 0.946 | 0.0407 | 0.840 |
a
Obtained by logistic regression analysis.
b
Obtained by multiple regression analysis.
DiAcSpd = N1,N8‐diacetylspermidine; DiAcSpm = N1,N12‐diacetylspermine; H&Y = Hoehn and Yahr stage; N1‐AcSpd = N1‐acetylspermidine; N1‐AcSpm = N1‐acetylspermine; N8‐AcSpd = N8‐acetylspermidine; Spd = spermidine; Spm = spermine; UPDRS‐III = Unified Parkinson's Disease Rating Scale motor section.