Figure 3.

Overall and subgroup (predefined based baseline levels) effects of an intensive lifestyle intervention vs. standard care on the occurrence of full or partial type 2 diabetes (T2D) remission at 24‐month follow‐up in participants with T2D. Young is defined as age < 54 years, based on a median split of age; short T2D duration as <5 years, based on a median split of disease duration, impaired glucose tolerance (IGT) as 2‐hour glucose concentration ≥ 11.1 mmol/L during an oral glucose tolerance test, impaired fasting glucose (IFG) as fasting glucose ≥7.0 mmol/L, low cardio‐respiratory fitness (CRF) as maximal oxygen consumption <2623 mL O₂/min, based on a median split of age, high‐dose glucose‐lowering medication (GLM) as >1000 mg metformin, and obesity as body mass index >30 kg/m². Per protocol indicates the presence of all the following criteria during the intervention: U‐TURN group: 1) attending at least four (of five) medical consultations, 2) completing ≥70% of all exercise sessions and 3) only receiving the prescribed medications and/or the prescribed combination of medications according to the treatment algorithm; standard care group: 1) attending at least four (of five) medical consultations and 2) only receiving the prescribed medications and/or the prescribed combination of medications according to the treatment algorithm. *Analyses are based on continuity corrected data. N/E, not estimeble