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Roles of mevalonate and isoprenoids in the translocation of Rho GTPase family in H-NCD. Rat cortical neurons incubated with mevalonate (0.03 mg/ml), GGPP in liposomes (4 μm), FPP in liposomes (4 μm), or vehicle for 72 hr in the presence of pravastatin (300 μm). Crude membrane- and cytosol-containing fractions were prepared as described in Materials and Methods. Each lysate (20 μg) was analyzed by immunoblotting with antibodies against Ras, Rho A, Rho B, and cdc42.
