Fig. 2.
Impaired paired-pulse inhibition in the CA1 region of the hippocampus of 5-HT1A receptor KO mice.A–D, Representative field potentials induced by paired-pulse stimuli presented at 10 (A,C) and 50 (B, D) msec intervals of WT (A, B) and KO (C, D) hippocampal slices. Paired-pulse inhibition–facilitation was measured as a percentage of the second to the first stimulus. E, Paired-pulse inhibition–facilitation in the CA1 hippocampal field of WT and KO mice, as a function of interpulse interval. The number of slices investigated per group were as follows: 10 mice/group; 2–3 slices per mouse; and 30 slices for WT and 22 for KO mice. *p< 0.05 represents significant differences between KO and WT animals.