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. 2000 Apr 1;20(7):2439–2450. doi: 10.1523/JNEUROSCI.20-07-02439.2000

Fig. 1.

Fig. 1.

Heterotopia of the Lis1+/−hippocampus. Nissl-stained sections of adult Lis1+/−mouse hippocampus reveal the cellular disorganization and heterotopia of the principal cell layers. A1, The normal wild-type hippocampus (5×) is characterized by tightly packed CA1 and CA3 pyramidal (A2, 25×) and granule cell layers (DG) (A3, 25×), typically only a few cells thick. In contrast, severe pyramidal neuron heterotopia exists in the Lis1+/− hippocampus (B1–B3, 5×). In CA1, the pyramidal cell layer is loosely packed, with cells forming distinct, multiple layers that radiate from the stratum oriens/alveus into the stratum radiatum (B2, 25×). In the dentate gyrus, the granule cell layer is similarly disorganized into a diffuse band. The upper blade of the dentate gyrus granule cells is more diffusely packed than the lower blade. The loose organization of the granule cell layer obscures the hilar–dentate gyrus border (B3, 25×). st o-a, Stratum oriens-alveus; st. rad, stratum radiatum; st. pyr, stratum pyramidale. Scale bars:A1, B1, 250 μm; A2,A3, B2, B3, 66 μm.