Fig. 4.
Semiquantitative analysis of regional alterations in immunoreactivity of GABAA receptor subunits. The relative differences of staining intensities measured as optical densities in sections from animals with focal cortical malformations compared with sham-operated animals are displayed for different neocortical areas. A schematic drawing of the evaluated regions is shown in the inset. Significant differences (p < 0.05) are indicated byasterisks. Within the microgyrus, receptor subunits α1, α5, and γ2 showed a significant decrease in immunoreactivity compared with sham-operated animals. In the adjacent Fr, a significant reduction is measured for all subunits, whereas in Par1 and Par2, subunits α2 and α5 were significantly decreased in Par2 and subunit γ2 was reduced in both areas.