Fig. 10.

Induction of chattering in a regular spiking neuron. A–D, Same data presented in increasingly fine detail by expanding the time base.A, Induction protocol. The spike discharge pattern was examined by injecting a 500 msec duration depolarizing current pulse once every 2 sec before and after constant depolarization for 16 sec.B, C, The neuron responds to the depolarizing current pulses with a train of single action potentials (except for a doublet at the beginning of the pulse) before tonic current injection. After current injection, the neuron now responds to the current pulse with the generation of repetitive bursts. Action potentials and their derivative reveal the presence of fast spike afterhyperpolarizations and afterdepolarization.