Fig. 1.
Developmental acceleration in AMPA receptor desensitization kinetics. Single exponential time constant of desensitization (τdes) versus embryonic age (E) of development. Glutamate (10 mm) was rapidly applied to patches excised from nMag neurons in slices at various stages of development. Shown below the axis are major developmental events during this time period. Fromleft, points are mean ± SEM of 6, 3, 9, 10, 8, 11, and 8 patches. Horizontal bars denote variation in developmental time points pooled for each data point.Inset, Scaled representative current traces excised from neurons at E11 (gray), E13.5 (dotted), and E18 (black).Traces are averages of 10–30 events. Time course of exchange (junction potential change) is illustratedabove the current traces.