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. 2000 Jul 1;20(13):4944–4953. doi: 10.1523/JNEUROSCI.20-13-04944.2000

Fig. 1.

Fig. 1.

MBP mRNA isoforms detected by the RPA analysis.A, Schematic representation of MBP mRNA isoforms in relation to the RPA probe. MBP mRNA isoforms encoding MBPs of 21.5, 18.5, 17.2, and 14 kDa are denoted as M21.5, M18.5, M17.2, and M14, respectively, with the predicted size for protected fragments indicated at the right. B, The RPA pattern of major MBP mRNA isoforms during development of normal C57/B6 mice and in an immortalized oligodendrocyte cell line N20.1. Five micrograms of total RNA was used in each RPA reaction. C, Increased ratio of M14/M21.5 during normal development. M14/M21.5 is significantly increased in adult animals (p < 0.001, one-way ANOVA), with SE indicated for each developmental point. *p < 0.05 in comparison to the adult.