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. 2000 Jul 15;20(14):5420–5436. doi: 10.1523/JNEUROSCI.20-14-05420.2000

Fig. 10.

Fig. 10.

Altering the membrane potential at a single-cell level affected the firing-rate selectivity of X-projecting neurons but not that of RA-projecting neurons. Mean firing-rate selectivity (d′) for forward versus reverse BOS playback was measured for 11 X-projecting neurons and 7 RA-projecting neurons at their normal membrane potentials and then during tonic depolarization with positive current (X-projecting, Vcontrol = −76.5 ± 2.1 mV vs Vdepolarized = −57.6 ± 3.5 mV; p < 0.001; n = 11 cells; RA-projecting, Vcontrol = −79.6 ± 2.8 mV vs Vdepolarized = −57.4 ± 3.2 mV;p < 0.0001; n = 8 cells).Left, In X-projecting neurons, this manipulation altered firing-rate selectivity (d′normal = 1.65 ± 0.22 vsd′depolarized = −1.21 ± 0.52;p < 0.005, paired t test), because of changes in suprathreshold responses to forward, but not reverse, BOS playback (see Fig. 9B). Right, In RA-projecting neurons, tonic depolarization did not alter firing-rate selectivity (d′control = 1.47 ± 0.21; d′depolarized = 1.54 ± 0.27; p = 0.85, paired t test), because of a parallel trend toward increased suprathreshold responsiveness to both forward and reverse BOS (see Fig.9B). The horizontalgraybar is the nonselective zone.