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. 2000 Jul 15;20(14):5234–5244. doi: 10.1523/JNEUROSCI.20-14-05234.2000

Fig. 8.

Fig. 8.

Normal LTP in the CA3 region of ST8SiaIV−/− mice.a, Stimulation of mossy fibers with a frequency of 0.33 Hz increased the amplitudes of fEPSPs in acute slices from both wild-type C57BL/6J and ST8SiaIV−/− mice (filled squares and empty circles, respectively). Data in a--c are from five wild-type and three ST8SiaIV−/− mice. Here and below, the graphs represent normalized mean + SEM, nprovides the number of tested slices. b, Application of the type II metabotropic glutamate receptor agonist L-CCGI (10 μm) reduced the amplitude of fEPSPs in slices from both wild-type and ST8SiaIV−/− mice.c, High-frequency stimulation (HFS, indicated by arrow) of mossy fibers evoked a similar increase in slopes of fEPSPs in slices from wild-type and ST8SiaIV−/− mice. Mean slope of fEPSPs recorded 0–10 min before HFS was taken as 100%.Insets show averaged fEPSPs recorded before and 60 min after induction of LTP in wild-type and ST8SiaIV−/− mice. Calibration: 10 msec, 100 μV. d, HFS of mossy fibers evoked similar LTP in slices with and without endo-N treatment. Recordings were performed in slices from five ST8SiaIV−/− mice.