Fig. 1.

PS1 mutant knock-in mice exhibit increased brain damage and behavioral deficits after focal ischemia-reperfusion. Wild-type and PS1 mutant mice were subjected to middle cerebral artery occlusion for 1 hr. Twenty two hours later neurological deficits were assessed (A), and at the 24 hr time point, the mice were killed, brain sections were stained with TTC, and infarct volume was quantified (B). Values are the mean and SE of analyses performed in 12 wild-type and 12 PS1 mutant mice. *p < 0.001 (infarct volume) andp < 0.01 (neurological deficit) compared to value for wild-type mice (paired t tests).