Fig. 1.
Top, Nucleotide and deduced amino acid sequence of mouse proSAAS. The amino acid sequences of the peptides found to be elevated in tissues fromCpefat/Cpefatmice are underlined (double underlineindicates those peptides found in both a short and long form).Bottom, Amino acid identity among human, rat, and mouse proSAAS. Asterisks below the sequence denote residues conserved in all three species. Open arrowhead, Signal peptide cleavage site. Double arrows, Paired basic cleavage sites (RR, KR) that are used in theCpefat/Cpefatmouse. Single arrows, KxxR cleavage site used in theCpefat/Cpefatmouse. Half arrows, Additional predicted cleavage sites. The sequences of the peptides that correspond to those found in theCpefat/Cpefatmice (but without the C-terminal basic residues that would be removed by active CPE) are indicated by lines.