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. 2000 Jan 15;20(2):834–844. doi: 10.1523/JNEUROSCI.20-02-00834.2000

Fig. 4.

Fig. 4.

a, Animal weight—NGF reduces mean body mass. NGF significantly affected the average body weight (F(5,38) = 14.89; p< 0.0001). NGF-treated animals had a significantly lower mean body mass, independent of the extent of lesioning. Animals were weighed weekly until the end of treatment. Data are expressed as means ± SEM. *Significant difference from the corresponding CytC group; PBS,p < 0.005; low-192Sap, p < 0.0001; high-192Sap, p < 0.0001. b,Animal weight—NGF decreases weight gain. Animals were continuously treated with NGF or CytC via intracerebroventricular cannulas. Body weights were measured week 0 (pump implantation), week 2, week 3.5 (pump change), week 5, and week 7 (end of treatment). NGF significantly altered weight gain throughout the treatment period (time-by-group interaction, F(20,152) = 15.06;p < 0.0001). In particular, NGF-treated animals never gained body mass similar to the corresponding CytC controls. Eachpoint represents the average body weight of the group during the treatment period. Open squares, PBS/CytC;closed squares, PBS/NGF; open circles, low-192Sap/CytC; closed circles, low-192Sap/NGF;open triangles, high-192Sap/CytC; closed triangles, high-192Sap/NGF.