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Cortical Trk tyrosine autophosphorylation after local BDNF administration. A, Three hours after a single injection of vehicle or BDNF (4 or 12 μg). B, Chronic infusion of vehicle or BDNF (4 μg/d) for 7 d. Trk P-tyr, Tyrosine-phosphorylated Trk; gp145 TrkB, total full-length (catalytic) TrkB protein; gp95 TrkB, truncated isoform of the TrkB protein; BDNF, exogenously delivered BDNF. Levels are quantified in Table 1.
