Fig. 9.

Representative photomicrographs of immunohistochemical study for active ERK in whole hippocampus immediately after ischemic insult in animals that received intraventricular injection of vehicle (A) and 30 μm PD98059 (B) 30 min before ischemic insult. In animals that received vehicle, immunoreactivity of the active form of ERK was the same as in animals that received only ischemic insult (A). Intraventricular injection of PD98059 markedly reduced the immunoreactivity (B). Scale bar, 1 mm.